Publications

Discovery of a Novel, Potent, and Selective 5‑Hydroxytryptamine 2B Receptor Antagonist that Induces Mitochondrial Biogenesis in the Kidney

This mechanistic study shows that MARY1 induced PGC-1α signaling depends on 5HTR2B and PI3K/MEK linked pathway engagement, supporting a mechanistically grounded mitochondrial biogenesis thesis. Read More

MARY1 Restores Mitochondrial Homeostasis and Accelerates Renal Recovery Following Acute Kidney Injury

This in vivo study showed that in rodent AKI models, MARY1 increased mitochondrial biogenesis markers and improved renal function during early recovery. Read more